Brief Overview of Our Proteomics Methods/Services

➢ Drug Target Identification/Deconvolution: Using our advanced & high-throughput Chemical Proteomics method: Five (5) drugs can now be scanned at the same time in parallel with 3 Biological replicates, removing all inter-assay variability! High specificity, deep profiling and at a very affordable price! (now also miniaturised for primary and iPSC derived cell cultures).

➢ Protein Expression Profiling: To deduce the mechanism of action of your drug candidate. This can also be done in parallel to your drug target finding, so it will save your precious time and money!

➢ ProTargetMiner: signature library of anticancer molecules, can be combined with other chemical proteomics methods.

➢ RedOx Proteomics: precisely quantify oxidative stress as a signature of disease progression or drug effect.

➢ HDX-MS analysis platform: It can be used to obtain information on your Protein Structure, its interaction sites (e.g., protein-protein or protein-ligand), Epitope Mapping, allosteric effects, intrinsic disorder, and conformational changes induced by post-translational modifications (PTMs). This technique is highly sensitive, and can able to detect co-existing protein conformations. 

➢ Large scale Quantitative Proteomics experiments using label-free or isobaric labelling (TMT and TMTpro) quantification strategies.

➢ Targeted Proteome Analysis, including SureQuant analysis of plasma/serum samples.

➢ Detection of Post-translational Modification and their localization on the amino acid sequence.

➢ General protein identification in gel and solution.

➢ Accurate molecular mass determination of peptides and small proteins.