- We
provide mass spectrometry-based method using thiol
trapping technique to precisely quantify oxidative stress
as a signature of disease progression or drug effect
in
in vivo, ex vivo and in vitro
preclinical samples, as well as clinical samples.
- This
method quantify oxidative
thiol modifications in hundreds of different proteins,
including physiologically important proteins,
in a single experiment.
- It
is especially
highly valuable for in vivo
studies for oxidative stress identification, which otherwise is very hard to
correctly identify and quantify.
